Symbol
Name
ID

Nr2f1
nuclear receptor subfamily 2, group F, member 1
MGI:1352451

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Optic nerve hypoplasia

Spasticity

Delayed myelination

Hypoplasia of the corpus callosum

Abnormal hippocampus morphology

Absent speech

Autistic behavior

Autism

Compulsive behaviors

Attention deficit hyperactivity disorder

Repetitive compulsive behavior

Intellectual disability

Global developmental delay

Seizure

Disease(s) Associated with NR2F1

Bosch-Boonstra-Schaaf optic atrophy syndrome

Mouse Phenotypes

nervous system phenotype

abnormal axon guidance

abnormal cochlear hair cell development

increased cochlear hair cell number

increased cochlear inner hair cell number

increased cochlear outer hair cell number

abnormal orientation of inner hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal brain commissure morphology

abnormal corpus callosum morphology

abnormal hippocampal commissure morphology

abnormal anterior commissure morphology

abnormal dorsal striatum morphology

abnormal cingulate gyrus morphology

decreased hippocampus volume

abnormal cerebral cortex morphology

increased neocortex volume

abnormal primary somatosensory cortex morphology

abnormal barrel cortex morphology

absent barrels in primary somatosensory cortex

abnormal neuron morphology

abnormal axon morphology

abnormal glossopharyngeal ganglion morphology

impaired synaptic plasticity

reduced long-term potentiation

abnormal long-term depression

Availability

Mouse Genotype

Nr2f1^tm1Mist/Nr2f1^tm1Mist

Nr2f1^tm1Mjts/Nr2f1^tm1Mjts

Nr2f1^tm1Mjts/Nr2f1⁺

Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist
Emx1^tm1(cre)Krj/Emx1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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